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RORB

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
Protein class

Disease related genes, Human disease related genes, Nuclear receptors, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Horizontal cells, Endometrial stromal cells, Astrocytes, Muller glia cells, Rod photoreceptor cells, Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (HHSteC, HSkMC, JURKAT, MOLT-4, SH-SY5Y)

Interaction

Monomer. Interacts with CRX.

Molecular function

Activator, Developmental protein, DNA-binding, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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