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ROS1
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Alveolar cells type 2)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (GAMG, HSkMC, hTCEpi, LHCN-M2)
Interaction
Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity). Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation.
Molecular function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
AGE-RAGE Signaling Pathway in Diabetic Complications
Amyotrophic Lateral Sclerosis
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- Derivation: Phage display library screening
- Species Reactivity: Rat, Human
- Type: IgG
- Application: WB
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- Species Reactivity: Human
- Application: FC, ICC/IF, IHC-Fr, IHC-P, IP, WB
- Mouse Anti-ROS1 Recombinant Antibody (MOB-0237F) (MOB-0237F)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.