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RPH3A
Exocytosis of neurotransmitters and hormones is fundamental to synaptic neurotransmission and cell-cell communication. RAB3A (MIM 179390) is a small G protein that is thought to act at late stages of exocytosis, and RPH3A is a RAB3A effector.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Excitatory neurons, Bipolar cells)
Immune cell specificity
Immune cell enhanced (classical monocyte)
Cell line specificity
Cell line enhanced (RPMI-8226, SH-SY5Y)
Interaction
Interacts with RAB3B, RAB3C, RAB3D, RAB8A, RAB27A and RAB27B (By similarity). Interacts with RAB3A; this interaction recruits RPH3A to synaptic vesicules (PubMed:15207266). Interacts (via C2B domain) with SNAP25 (By similarity). Interacts with deubiquitinating enzyme CAND1; this interaction results in the deubiquitination of RPH3A (By similarity). Interacts with GRIN2A and DLG4; this ternary complex regulates NMDA receptor composition at postsynaptic membranes (By similarity). Interacts with SNCA (PubMed:15207266).
More Types Infomation
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- Species Reactivity: Mouse, Rat, Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, ELISA
- Recombinant Anti-Human RPH3A Antibody scFv Fragment (MOB-2583z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IF, Neut, FuncS
- Recombinant Anti-Human RPH3A Antibody Fab Fragment (MOB-2583z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, RIA, FuncS
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- Derivation: Phage display library screening
- Species Reactivity: Rat
- Type: IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.