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RSPO1
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Breast myoepithelial cells, Breast glandular cells, Fibroblasts, Langerhans cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (NTERA-2, THP-1)
Interaction
Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). Interacts with ZNRF3; promoting indirect interaction between ZNRF3 and LGR4 and membrane clearance of ZNRF3. Interacts with LGR4, LGR5 and LGR6. Identified in a complex composed of RNF43, LGR5 and RSPO1. Interacts (via FU repeats) with KREM1 (PubMed:17804805).
Molecular function
Heparin-binding
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA
- Recombinant Rat Anti-Rspo1 Antibody (CBL882) (NEUT-1922CQ)
-
- Species Reactivity: Mouse
- Type: IgG2
- Application: Neut
- Recombinant Rat Anti-Rspo1 Antibody (CBL663) (NEUT-1921CQ)
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- Species Reactivity: Mouse
- Type: IgG2b
- Application: Neut
- Mouse Anti-RSPO1 Recombinant Antibody; Fab Fragment (HPAB-0021-DJB-F(E)) (HPAB-0021-DJB-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: Block
- Mouse Anti-RSPO1 Recombinant Antibody; Fab Fragment (TAB-345CT-F(E)) (TAB-345CT-F(E))
-
- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, ELISA, BL, IP
- Mouse Anti-RSPO1 Recombinant Antibody; Fab Fragment (TAB-344CT-F(E)) (TAB-344CT-F(E))
-
- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, ELISA, BL, FC, IP
- Mouse Anti-RSPO1 Recombinant Antibody (HPAB-0021-DJB) (HPAB-0021-DJB)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, Inhib, FuncS
- Anti-Human RSPO1 Therapeutical Antibody (TAB-766CL)
-
- Species Reactivity: Human
- Type: Antibody
-
- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA, BL, IP
-
- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA, BL, FC, IP
- Mouse Anti-RSPO1 Recombinant Antibody (clone 7A6) (VS3-XY1391)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Human Anti-RSPO1 Recombinant Antibody (HPAB-0020-DJB) (HPAB-0020-DJB)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FC, Block
- Mouse Anti-RSPO1 Recombinant Antibody; scFv Fragment (HPAB-0021-DJB-S(P)) (HPAB-0021-DJB-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Block
- Human Anti-RSPO1 Recombinant Antibody; scFv Fragment (HPAB-0020-DJB-S(P)) (HPAB-0020-DJB-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: Block
- Human Anti-RSPO1 Recombinant Antibody; Fab Fragment (HPAB-0020-DJB-F(E)) (HPAB-0020-DJB-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Block
-
- Species Reactivity: Human
- Type: ADCC enhanced antibody
-
- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, BL, IP
-
- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, BL, FC, IP
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For Research Use Only. Not For Clinical Use.