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S100A12

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.
S100A12
Protein class

Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (monocytes, Kupffer cells, Macrophages)

Immune cell specificity

Group enriched (neutrophil, classical monocyte)

Cell line specificity

Cell line enhanced (hTCEpi, THP-1)

Interaction

Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts with AGER and both calcium and zinc are essential for the interaction. Interacts with CACYBP in a calcium-dependent manner.

Molecular function

Antibiotic, Antimicrobial, Fungicide

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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