Cancer-related genes, Plasma proteins
Intracellular, Secreted (different isoforms)
Cell type enhanced (Langerhans cells, monocytes, Macrophages, Kupffer cells, NK-cells, T-cells, Skeletal myocytes)
Low immune cell specificity
Cell line enhanced (A549, ASC diff, BJ hTERT+, fHDF/TERT166, RPMI-8226)
Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (PubMed:11836260). Interacts with PGLYRP1; this complex acts as a chemoattractant that promotes lymphocyte movement (PubMed:30713770, PubMed:26654597). Interacts with MYH9; this interaction increases cell motility (PubMed:16707441). Interacts with Annexin 2/ANXA2 (PubMed:28669632). Interacts with TP53; this interaction promotes TP53 degradation (PubMed:23752197, PubMed:32442400). Interacts with CCR5 (PubMed:30713770). Interacts with FCGR3A; this interaction inhibits PKC-dependent phosphorylation of FCGR3A.
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For Research Use Only. Not For Clinical Use.