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S100A6
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells, Urothelial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (OE19, RPTEC TERT1)
Interaction
Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (PubMed:33831707).
More Types Infomation
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB
- Chicken Anti-S100A6 Polyclonal IgY (BRD-0523MZ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-P
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IHC-P
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.