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SCG3

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.
Protein class

Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Enteroendocrine cells, Horizontal cells, Bipolar cells, Cone photoreceptor cells, Rod photoreceptor cells, Astrocytes, Inhibitory neurons, Oligodendrocyte precursor cells, Excitatory neurons, Ionocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (NTERA-2, SCLC-21H, SH-SY5Y)

Interaction

Interacts with CHGA (PubMed:19357184) (By similarity). Interacts with secretogranin II/SCG2 (PubMed:19357184). Interacts (via C-terminus) with CPE (By similarity).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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