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SCN10A
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.
Molecular function
Ion channel, Sodium channel, Voltage-gated channel
More Types Infomation
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- Species Reactivity: Human
- Application: ICC/IF, WB, IHC-P, IHC-Fr, ICC
- Rabbit Anti-Scn10a Polyclonal Antibody (MRO-2058-CN) (MRO-2058-CN)
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- Species Reactivity: Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.