Disease related genes, FDA approved drug targets, Human disease related genes, Transporters, Voltage-gated ion channels
Intracellular, Membrane (different isoforms)
Group enriched (Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)
Not detected in immune cells
Group enriched (ASC TERT1, Hep G2)
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-4 (SCN4B). Beta-1 (SCN1B) and beta-3 (SCN3B) are non-covalently associated with alpha, while beta-2 (SCN2B) and beta-4 (SCN4B) are covalently linked by disulfide bonds. Interacts with FGF13 (PubMed:21566136). Interacts with SCN1B (PubMed:17928445, PubMed:15525788). Interacts with the conotoxin GVIIJ (PubMed:24497506). Interacts with the spider beta/delta-theraphotoxin-Pre1a (PubMed:28428547).
Ion channel, Sodium channel, Voltage-gated channel
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For Research Use Only. Not For Clinical Use.