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SCNN1A
The SCNN1A gene encodes for the α subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1B, SCNN1G, and SCNN1D.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Distal enterocytes, Glandular and luminal cells, Intestinal goblet cells, Collecting duct cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (CAPAN-2, HBEC3-KT, hTCEpi, RPTEC TERT1, RT4, SK-BR-3)
Interaction
Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties (By similarity). Interacts with NEDD4 (via WW domains) (PubMed:11244092, PubMed:11696533, PubMed:12167593, PubMed:23665454). Interacts with NEDD4L (via WW domains) (PubMed:11244092, PubMed:11696533). Interacts with WWP1 (via WW domains) (PubMed:9169421). Interacts with WWP2 (via WW domains) (PubMed:12167593, PubMed:9169421). Interacts with the full-length immature form of PCSK9 (pro-PCSK9) (PubMed:22493497).
Molecular function
Ion channel, Sodium channel
More Types Infomation
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, IHC, FC
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- Species Reactivity: Human
- Type: Human IgG
- Application: WB, ELISA, IHC, FC
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, IHC, FC
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For Research Use Only. Not For Clinical Use.