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SEMA6A
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection.
Protein class
Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Oligodendrocytes, Hepatic stellate cells, Oligodendrocyte precursor cells, Horizontal cells, Cytotrophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AN3-CA, HAP1, NTERA-2, SuSa)
Interaction
Active as a homodimer or oligomer (By similarity). The SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer (By similarity). Interacts with EVL (PubMed:10993894). (Microbial infection) Interacts with P. sordellii toxin TcsL; semaphorins SEMA6A and SEMA6B constitute the major host receptors for TcsL in the vascular endothelium.
Molecular function
Developmental protein
More Types Infomation
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- Species Reactivity: Human
- Type: IgG
- Application: ELISA
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.