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SEMG1

Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
Protein class

Plasma proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Basal prostatic cells, Prostatic glandular cells)

Immune cell specificity

Immune cell enriched (eosinophil)

Cell line specificity

Cell line enhanced (NTERA-2, THP-1)

Interaction

Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both binding to EPPIN.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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