Serpinb8

Serpins are the largest and mostdiverse family of serine protease inhibitors which are involved in a number offundamental biological processes such as blood coagulation, complementactivation, fibrinolysis, angiogenesis, inflammation and tumor suppression andare expressed in a cell-specific manner.Mouse SerpinB8, also known asCytoplasmic antiproteinase 2, Peptidase inhibitor 8, SerpinB8, PI-8, SERPINB8and CAP2, is a member of the Serpin superfamily. SERPINB8 was broadlyexpressed. In normal neuroendocrine tissues, strongest SerpinB8 expression wasdetected in islets of Langerhans of the pancreas. Moderate SerpinB8 expressionwas observed in neuroendocrine cells of the thyroid, adrenal cortex, colon, andpituitary gland. In the pancreas, SerpinB8 is specifically expressed byinsulin-producing beta cells, and can be used as an additional diagnosticimmunohistochemical marker. Mouse SerpinB8 distribution alters during kidneyregeneration, possibly to control a prohormone convertase involved ininflammation or tissue repair.