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SESN2
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (hTCEpi, SK-MEL-30)
Interaction
Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine (PubMed:25263562, PubMed:25457612, PubMed:26449471). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). May interact with the TORC2 complex (By similarity). Interacts with KEAP1, RBX1, SQSTM and ULK1; to regulate the degradation of KEAP1 (PubMed:23274085, PubMed:25040165). May also associate with the complex composed of TSC1, TSC2 and the AMP-responsive protein kinase/AMPK to regulate TORC1 signaling (PubMed:18692468). May interact with PRDX1 (PubMed:15105503).
Molecular function
Oxidoreductase
More Types Infomation
- Recombinant Mouse Anti-Human SESN2 Antibody (MOB-1836MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
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For Research Use Only. Not For Clinical Use.