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SFN
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Squamous epithelial cells, Urothelial cells, Basal prostatic cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi)
Interaction
Homodimer (PubMed:28202711). Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with COP1; this interaction leads to proteasomal degradation. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711).
More Types Infomation
- Recombinant Rabbit Anti-SFN Monoclonal Antibody (SD2070) (MRO-0007-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IHC
- Recombinant Mouse Anti-Human SFN Antibody (MOB-2173MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
- Chicken Anti-SFN Polyclonal IgY (BRD-0529MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
- Rabbit Anti-SFN Recombinant Antibody (VS3-CJ877) (VS3-CJ877)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.