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SIK2
Phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Protein class
Enzymes, Metabolic proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Excitatory neurons, Oligodendrocytes, Inhibitory neurons, Astrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC diff)
Interaction
Interacts with and phosphorylates TORC2/CRTC2.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
- Recombinant Mouse Anti-Human SIK2 Antibody (MOB-1663MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.