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SIRPB1

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class

CD markers, Plasma proteins, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Macrophages, Kupffer cells, monocytes, Hofbauer cells, dendritic cells)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Group enriched (HMC-1, NB-4, THP-1)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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