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SLC4A4

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Astrocytes, Distal enterocytes, Proximal tubular cells, Cholangiocytes, Ductal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, fHDF/TERT166, HBF TERT88, hTERT-RPE1, RPTEC TERT1, U-138 MG)

Interaction

Homodimer (PubMed:29500354). Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity (PubMed:12411514, PubMed:14567693, PubMed:15218065, PubMed:15563508). Isoform 1 but not isoform 2 interacts with AHCYL1 (via PEST domain when phosphorylated); the interaction increases SLC4A4 isoform 1 activity (PubMed:16769890). Interacts with AHCYL2 (By similarity).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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