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SLC4A7

This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein class

Metabolic proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Cone photoreceptor cells, Rod photoreceptor cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (hTERT-HME1)

Interaction

Interacts with CFTR through SLC9A3R1/EBP50. Interacts with USH1C. Forms a complex with ATP6V1B1 and SLC9A3R1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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