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SLC5A7
Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., 2000 [PubMed 11027560]).
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Club cells, Respiratory ciliated cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (RT4, SCLC-21H)
Interaction
Homooligomerizes at cell surface (PubMed:23132865). Interacts with SEC14L1; may regulate SLC5A7 (PubMed:17092608).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IHC, FuncS
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For Research Use Only. Not For Clinical Use.