Metabolic proteins, Transporters
Membrane
Cell type enhanced (Basal squamous epithelial cells, Plasma cells, Microglial cells, Syncytiotrophoblasts)
Immune cell enriched (plasmacytoid DC)
Cell line enhanced (HBEC3-KT, hTCEpi, MCF7, SiHa)
Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:10049700, 10391915, 10574970, 11311135, 11389679, 11557028, 11564694, 12117417, 12225859, 15769744, 9751058, 25998567, 30867591). Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2/4F2hc and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).
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For Research Use Only. Not For Clinical Use.