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SLC7A5

SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases associated with SLC7A5 include Lysinuric Protein Intolerance and Phenylketonuria. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and Amino acid transport across the plasma membrane. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and antiporter activity.
Protein class

Metabolic proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Basal squamous epithelial cells, Plasma cells, Microglial cells, Syncytiotrophoblasts)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Cell line enhanced (HBEC3-KT, hTCEpi, MCF7, SiHa)

Interaction

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:10049700, 10391915, 10574970, 11311135, 11389679, 11557028, 11564694, 12117417, 12225859, 15769744, 9751058, 25998567, 30867591). Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2/4F2hc and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).

More Types Infomation

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