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TNFRSF17

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Protein class

Cancer-related genes, CD markers, Disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enriched (Plasma cells)

Immune cell specificity

Group enriched (memory B-cell, naive B-cell, plasmacytoid DC)

Cell line specificity

Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)

Interaction

Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.

Molecular function

Receptor

More Types Infomation
    • Target: BCMA (B-Cell Maturation Antigen)
    • Linker: PEG4-Mal
    • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
    • Target: BCMA
    • Linker: mc (maleimidocaproyl)
    • Drug: MMAF (monomethyl auristatin F)
    • Target: BCMA (B-Cell Maturation Antigen)
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    • Target: BCMA (B-Cell Maturation Antigen)
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    • Target: BCMA (B-Cell Maturation Antigen)
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    • Target: BCMA (B-Cell Maturation Antigen)
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

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