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Tetravalent Heavy Chain-only Antibody (hCAb)

Creative Biolabs possesses unchallenged experience in synthesis of tetravalent heavy chain-only antibodies (hcAbs). Multiple platforms of Creative Biolabs are elaborately integrated for providing customer an expected tetravalent hcAb with high affinity and low immunogenicity for both academic and clinical purposes.


Figure: Diagram of a tetravalent hcAb structure

Unlike conventional mammal antibody, camelid hcAb only has a pair of heavy chains consisting of constant domain and variable domain (VHH). Benefited by its simple structure and tiny size, hcAb and its artificial derivatives are well-known for their outstanding performance in tissue penetrating, antigen recognizing and binding, and resistance to physical and chemical impact. To further enhance its effect, tetravalent hcAb is developed as a novel bispecific hcAb format. Usually, two VHH domains with distinct specificity are sub-cloned into a eukaryotic expression vector. Meanwhile, a DNA fragment coding a human IgG2 or IgG3 constant region without CH1 is introduced between VHH domains. As a result, artificial bispecific chains consisting of tandem VHH1, hCH2, hCH3 and VHH2 are expressed. Taking advantage of the interaction between human IgG constant regions, bispecific tetravalent antibodies can be effectively generated. These bispecific antibodies can keep the specificity and binding affinity of their parental antibodies. More importantly, the tetravalent complex is more effective at a lower dose, which would show more options for physicians in disease treatment.

Creative Biolabs can take all concerns of customer into serious consideration for designing a budget and time-saving working procedure. With our outstanding recombinant antibody synthesis platform, Creative Biolabs is confident of providing desired tetravalent hcAbs with experimentally verified high-affinity and reliable safety.

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