Anti-CD79b (clone ch10D10)-BMPEO-DM1 ADC (CAT#: ADC-055CL)

This ADC product is composed of an anti-CD79b antibody (clone ch10D10) conjugated via BMPEO linker to DM1(thio anti-cynoCD79b (ch10D10)-HC(A118C)-BMPEO-DM1). It has demonstrated a response in hematopoietic tumors treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • A118C Thio Anti-cynoCD79b (ch10D10)-HC(A118C)
  • Clone
  • ch10D10
  • Antibody Conjugation
  • Thio
  • Linker
  • BMPEO (bis-maleimido-trioxyethylene glycol)
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

  • Introduction
  • The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);

Related Resources

  • Related Signaling Pathways

Downloads

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See other products for "Clone ch10D10"

See other products for "CD79B"

Humanized Antibody

CAT Product Name Application Type
TAB-897 Humanized Anti-CD79B Recombinant Antibody (clone Polatuzumab) Neut, ELISA, IF, IP, FuncS, FC, ICC Humanized (from mouse) IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0581 Hi-Affi™ Rabbit Anti-CD79B Recombinant Antibody (clone DS581AB) WB, IHC, ICC, IP, FC Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1918 PE-A*02:01/Human CD79B (LLSAEPVPA) MHC Tetramer FCM

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-897 Afuco™ Anti-CD79B ADCC Recombinant Antibody (Polatuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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