Anti-CD79b (clone huMA79b.v18)-MCvcPAB-MMAE ADC (CAT#: ADC-050CL)

This ADC product is composed of an anti-CD79b antibody (clone huMA79b.v18) conjugated via MCvcPAB linker to MMAE(thio huMA79b.v18-HC(A118C)-MCvcPAB-MMAE). It has demonstrated a response in hematopoietic tumors treatment by a MOA (Mechanism of Action) as microtubule inhibitor.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized Cysteine engineered Anti-CD79b Antibody (Thio-huMA79b.v18-HC-A118C)
  • Clone
  • huMA79b.v18
  • Antibody Conjugation
  • Thio
  • Linker
  • MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Linker Class/Description
  • Class: Enzymatically cleavable linkers-Peptide linkers
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);

Related Resources

  • Related Signaling Pathways

Downloads

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See other products for "Clone huMA79b.v18"

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Humanized Antibody

CAT Product Name Application Type
TAB-897 Humanized Anti-CD79B Recombinant Antibody (clone Polatuzumab) Neut, ELISA, IF, IP, FuncS, FC, ICC Humanized (from mouse) IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0581 Hi-Affi™ Rabbit Anti-CD79B Recombinant Antibody (clone DS581AB) WB, IHC, ICC, IP, FC Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1918 PE-A*02:01/Human CD79B (LLSAEPVPA) MHC Tetramer FCM

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-897 Afuco™ Anti-CD79B ADCC Recombinant Antibody (Polatuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

Recombinant Antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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