transferrin-Gel immunotoxin (AGTO-G074G)
This immunotoxin was achieved by conjugating/fusing the transferrin to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating myelogenous leukemia.
- Species Reactivity
- Molecule Class
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- myelogenous leukemia
- Alternative Names
- BDP1; B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB; TFC5; TFNR; TAF3B1; TFIIIB; TFIIIB90; HSA238520
- Entrez Gene ID
- UniProt ID
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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