transferrin-RTA immunotoxin (CAT#: AGTO-L076R)

This immunotoxin was achieved by conjugating/fusing the transferrin to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TFRC expressing cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Human
  • Species Reactivity
  • Human
  • Molecule Class
  • transferrin-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases

Target

  • Alternative Names
  • CD 71; CD71; CD71 antigen; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; p90; sTfR; T9; TFR 1; TfR; TfR1; TFR1_HUMAN; TFRC; TR; Transferrin receptor (p90 CD71); Transferrin receptor protein 1, serum form; Trfr; T cell leukemias; lymphomas; graft- versus-host diseases; autoimmune diseases; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "TFRC"

Immunotoxin

CAT Product Name Application Type
AGTO-G067E Anti-TFRC immunotoxin HB21 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G067D Anti-TFRC immunotoxin HB21 (scFv)-DT Cytotoxicity assay, Function study
AGTO-G067G Anti-TFRC immunotoxin HB21 (scFv)-Gel Cytotoxicity assay, Function study
AGTO-G067R Anti-TFRC immunotoxin HB21 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G067S Anti-TFRC immunotoxin HB21 (scFv)-Sap Cytotoxicity assay, Function study

Blocking Antibody

CAT Product Name Application Type
NEUT-1999CQ Rat Anti-Tfrc Recombinant Antibody (clone RI7217) FC, ICC, IP, WB, Block Rat IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3548 Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) FC, IP, WB Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
FAMAB-0281YC Mouse Anti-TFRC Recombinant Antibody (clone OX26) ELISA Mouse IgG
HPAB-0238-YJ Rat Anti-TFRC Recombinant Antibody (HPAB-0238-YJ) IHC, FC, WB, FuncS Rat IgG2a
HPAB-0239-YJ Mouse Anti-TFRC Recombinant Antibody (HPAB-0239-YJ) IHC, FC, WB, FuncS Chimeric (mouse/rat) IgG1, κ
HPAB-0240-YJ Mouse Anti-TFRC Recombinant Antibody (HPAB-0240-YJ) IHC, FC, WB, FuncS Chimeric (mouse/rat) IgG1, κ
FN-245CQ Mouse Anti-TFRC Recombinant Antibody (clone OKT9) FC, FuncS, IHC Mouse IgG1, κ

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for AGTO-L076R. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare