Anti-CD20-MCC-DM1 ADC (CAT#: ADC-186LZY)

This ADC product is composed of an anti-CD20 antibody conjugated via MCC linker to DM1 (MCC-DM1). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Linker
  • MCC (Maleimidomethyl cyclohexane-1-carboxylate)
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;

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Humanized Antibody

CAT Product Name Application Type
TAB-772 Human Anti-MS4A1 Recombinant Antibody (TAB-772) ELISA, IP, FC, FuncS, Neut, IF, ICC IgG1
TAB-771 Humanized Anti-MS4A1 Recombinant Antibody (TAB-771) IF, IP, Neut, FuncS, ELISA, FC, ICC Humanized IgG1, κ
TAB-537CL Human Anti-MS4A1 Recombinant Antibody (TAB-537CL) ELISA Human IgG
TAB-1638CL Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL) ADCC, CDC Humanized IgG
TAB-1639CL Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL) ADCC, CDC, Apop Humanized IgG

Recombinant Antibody

CAT Product Name Application Type
PABW-019 Human Anti-MS4A1 Recombinant Antibody (clone C2H7) WB, IF, FuncS Chimeric (mouse/human) IgG
FAMAB-0144-CN Human Anti-MS4A1 Recombinant Antibody (clone C2B8) WB, ELISA Chimeric (mouse/human) IgG1
HPAB-0247-FY Human Anti-MS4A1 Recombinant Antibody (clone EM201) Inhib, ELISA Humanized IgG1
HPAB-1896LY Mouse Anti-MS4A1 Recombinant Antibody (clone muCD37-3) ELISA, Inhib Mouse IgG
HPAB-1897LY Human Anti-MS4A1 Recombinant Antibody (clone chCD37-3) ELISA, Inhib Chimeric (mouse/human) IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-1665CL Human Anti-MS4A1 Recombinant Antibody (TAB-1665CL) CDC Chimeric (mouse/human) IgG
TAB-1666CL Human Anti-MS4A1 Recombinant Antibody (TAB-1666CL) CDC Chimeric (mouse/human) IgG
TAB-1667CL Human Anti-MS4A1 Recombinant Antibody (TAB-1667CL) CDC Chimeric (mouse/human) IgG
TAB-1668CL Human Anti-MS4A1 Recombinant Antibody (TAB-1668CL) CDC Chimeric (mouse/human) IgG
TAB-1669CL Human Anti-MS4A1 Recombinant Antibody (TAB-1669CL) CDC Chimeric (mouse/human) IgG

Hyper-galactosylated

High-mannose Glycoform

CAT Product Name Application Type
Gly-155LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-171LC Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) ELISA Chimeric antibody (mouse/human)

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1751CQ Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) Neut, FuncS Mouse IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-772 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-016 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-028 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-207 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-771 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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