10-FnIII scaffold protein anti-Human αvβ3 Integrin (CAT#: SFN-L032)
The tenth fibronectin type III domain (10Fn3) that bound αvβ3 Integrin was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=800 pM) for αvβ3 Integrin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Specifications
- Scaffold Name
- 10-FnIII
- Origin
- Fibronectin
- Core Structure
- β-sandwich of 7 β-strands
- Variable Regions
- 2–3 Loops
- Target
- αvβ3 Integrin
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3) cells
- Affinity Constant
- 800 pM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
- Alternative Names
- Fibronectin; 10-FnIII; αvβ3 Integrin; αVβ3; integrin
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-705 | Anti-αvβ3 Integrin Recombinant Antibody (Etaracizumab/Etaratuzumab/Medi-522) | FC, IP, ELISA, Neut, FuncS, IF, IHC | IgG2 - kappa |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-705 | Afuco™ Anti-αVβ3 Integrin ADCC Recombinant Antibody (Etaracizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1305WJ | Human Anti-αvβ3 Integrin Recombinant Antibody (clone LM609) | ELISA | Humanized IgG |
| HPAB-A1325-YJ | Mouse Anti-αvβ3 Integrin Recombinant Antibody (clone D12) | ELISA, Inhib, FC | Mouse IgG1 |
| HPAB-A1326-YJ | Human Anti-αvβ3 Integrin Recombinant Antibody (clone chD12) | ELISA, Inhib, FC | Chimeric (mouse/human) IgG1 |
| HPAB-A1327-YJ | Human Anti-αvβ3 Integrin Recombinant Antibody (clone huD12) | ELISA, Inhib, FC | Humanized IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1305WJ-S(P) | Human Anti-αvβ3 Integrin Recombinant Antibody (clone LM609); scFv Fragment | ELISA | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1305WJ-F(E) | Human Anti-αvβ3 Integrin Recombinant Antibody (clone LM609); Fab Fragment | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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