Anti-NTB-A (clone 26B7)-vc-MMAE ADC (CAT#: ADC-362CL)

• Antibody Overview
• Murine Anti-NTB-A monoclonal Antibody 26B7

• Clone
• 26B7

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

• Alternative Names
• SLAMF6; SLAM family member 6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000; NTBA receptor; NK-T-B-antigen; activating NK receptor; natural killer-, T-and B-cell antigen;

• Gene ID
• 114836

• UniProt ID
• Q96DU3

• ADC-363CL
• Anti-NTB-A (clone 26B7)-mc-MMAF ADC

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