Anti-BCMA (clone 2A1)-SMCC-DM1 ADC

Name: Anti-BCMA (clone 2A1)-SMCC-DM1 ADC
SKU: ADC-151CL
Rating: 5 (1 reviews)

CAT#: ADC-151CL

This ADC product is composed of an anti-BCMA (B-Cell Maturation Antigen) antibody (clone 2A1) conjugated via SMCC linker to DM1(2A1-MCC-DM1). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000048462-TNFRSF17

❮

❯

Specifications

Antibody Overview
Fully Human BCMA Antibody 2A1

Clone
2A1

Linker
SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)

Linker Class/Description
Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

Drug
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

Drug Class/Description
Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

Alternative Names
TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF13A; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein;

Gene ID
608

UniProt ID
Q02223

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for ADC-151CL. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - ADC-151CL.pdf

MSDS

MSDS - ADC-151CL.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "Clone 2A1"

CAT
Product Name

See other products for "TNFRSF17"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-1620z	Mouse Anti-TNFRSF17 Recombinant Antibody (clone 2A10)	WB, ELISA, FC	Mouse IgG1

CAT	Product Name	Application	Type
PABL-019	Mouse Anti-TNFRSF17 Recombinant Antibody (clone J22.9-xi)	ELISA, FC, Neut, FuncS	Mouse IgG

CAT	Product Name	Application	Type
PSBL-019	Mouse Anti-TNFRSF17 Recombinant Antibody (clone J22.9-xi); scFv Fragment	Neut, FuncS	Mouse scFv

CAT	Product Name	Application	Type
PFBL-019	Mouse Anti-TNFRSF17 Recombinant Antibody (clone J22.9-xi); Fab Fragment	Neut, FuncS	Mouse Fab

CAT	Product Name	Application	Type
TAB-0137CL	Mouse Anti-TNFRSF17 Recombinant Antibody (TAB-0137CL)	FC, Block, IB, Cyt, IF	Mouse IgG1, κ

CAT	Product Name	Application	Type
TAB-1207CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1207CL)	ELISA, FC, FuncS	Chimeric (rat/human) IgG

CAT	Product Name	Application	Type
TAB-1208CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1208CL)	ELISA, FC	Human antibody

CAT	Product Name	Application	Type
TAB-1209CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1209CL)	ELISA, FC	Human antibody

CAT	Product Name	Application	Type
TAB-1210CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1210CL)	ELISA, FC	Human antibody

CAT	Product Name	Application	Type
TAB-1211CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1211CL)	ELISA, FC	Human antibody

CAT	Product Name	Application	Type
TAB-1212CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1212CL)	ELISA, FC	Human antibody

CAT	Product Name	Application	Type
TAB-1218CL	Mouse Anti-TNFRSF17 Recombinant Antibody (TAB-1218CL)	ELISA	Mouse IgG

CAT	Product Name	Application	Type
TAB-1219CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1219CL)	ELISA, FC, Block, Cyt, FuncS	Chimeric (Mouse/Human) IgG1

CAT	Product Name	Application	Type
TAB-1220CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1220CL)	ELISA, Cyt, FC	Humanized antibody

CAT	Product Name	Application	Type
TAB-1221CL	Anti-Human TNFRSF17 Recombinant Antibody (TBL-CLN1)	Cyt

CAT	Product Name	Application	Type
TAB-1222CL	Mouse Anti-TNFRSF17 Recombinant Antibody (TAB-1222CL)	FC	Mouse IgG1

CAT	Product Name	Application	Type
TAB-1226CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1226CL)	FuncS	Chimeric (mouse/human) IgG

CAT	Product Name	Application	Type
TAB-1227CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1227CL)	FuncS	Chimeric (mouse/human) IgG

CAT	Product Name	Application	Type
TAB-1228CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1228CL)	FuncS	Chimeric (mouse/human) IgG

CAT	Product Name	Application	Type
TAB-1229CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1229CL)	FuncS	Chimeric (mouse/human) IgG

CAT	Product Name	Application	Type
TAB-1230CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1230CL)	ELISA	Humanized IgG

CAT	Product Name	Application	Type
TAB-1231CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1231CL)	ELISA	Humanized IgG

CAT	Product Name	Application	Type
TAB-1232CL	Human Anti-TNFRSF17 Recombinant Antibody (TAB-1232CL)	ELISA	Humanized IgG

CAT	Product Name	Application	Type
TAB-1220CL-S(P)	Human Anti-TNFRSF17 Recombinant Antibody; scFv Fragment (TAB-1220CL-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
MOB-0250CT	Recombinant Mouse anti-Human TNFRSF17 Monoclonal antibody (EML209)	ELISA, WB

CAT	Product Name	Application	Type
NEUT-2125CQ	Rat Anti-TNFRSF17 Recombinant Antibody (clone 3D44)	Neut, WB	Rat IgG2

CAT	Product Name	Application	Type
NEUT-2126CQ	Rat Anti-TNFRSF17 Recombinant Antibody (clone Vicky-1)	WB, Neut, ELISA, FC, ICC, IF, IHC	Rat IgG1

CAT	Product Name	Application	Type
NEUT-2127CQ	Rat Anti-TNFRSF17 Recombinant Antibody (clone CBL370)	WB, Block	Rat IgG2a

CAT	Product Name	Application	Type
NEUT-2128CQ	Rat Anti-Tnfrsf17 Recombinant Antibody (clone 17B1)	Neut, WB	Rat IgG2

CAT	Product Name	Application	Type
NEUT-2129CQ	Rat Anti-Tnfrsf17 Recombinant Antibody (clone CBL336)	Block, WB	Rat IgG2a

CAT	Product Name	Application	Type
NEUT-2130CQ	Mouse Anti-Tnfrsf17 Recombinant Antibody (clone CBL337)	Block	Mouse IgG1

CAT	Product Name	Application	Type
NEUT-2131CQ	Rat Anti-Tnfrsf17 Recombinant Antibody (clone Vicky-2)	WB, Neut, FC, IP	Rat IgG2a

CAT	Product Name	Application	Type
NEUT-2132CQ	Rat Anti-Tnfrsf17 Recombinant Antibody (clone CBL183)	Neut, WB	Rat IgG2

CAT	Product Name	Application	Type
HPAB-0009-DJB	Mouse Anti-TNFRSF17 Recombinant Antibody (HPAB-0009-DJB)	ELISA, Neut, FC, SPR, ADCC, FuncS	Mouse IgG

CAT	Product Name	Application	Type
HPAB-0010-DJB	Human Anti-TNFRSF17 Recombinant Antibody (HPAB-0010-DJB)	ELISA, Neut, ADCC	Humanized IgG

CAT	Product Name	Application	Type
HPAB-0009-DJB-S(P)	Mouse Anti-TNFRSF17 Recombinant Antibody scFv Fragment (HPAB-0009-DJB-S(P))	ELISA, Neut	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0010-DJB-S(P)	Human Anti-TNFRSF17 Recombinant Antibody; scFv Fragment (HPAB-0010-DJB-S(P))	ELISA, Neut	Humanized scFv

CAT	Product Name	Application	Type
HPAB-0011-DJB-S(P)	Mouse Anti-TNFRSF17 Recombinant Antibody; scFv Fragment (HPAB-0011-DJB-S(P))	ELISA, FC	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0012-DJB-S(P)	Mouse Anti-TNFRSF17 Recombinant Antibody; scFv Fragment (HPAB-0012-DJB-S(P))	ELISA, FC	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0009-DJB-F(E)	Mouse Anti-TNFRSF17 Recombinant Antibody Fab Fragment (HPAB-0009-DJB-F(E))	ELISA, Neut	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0010-DJB-F(E)	Human Anti-TNFRSF17 Recombinant Antibody; Fab Fragment (HPAB-0010-DJB-F(E))	ELISA, Neut	Humanized Fab

CAT	Product Name	Application	Type
HPAB-0011-DJB-F(E)	Mouse Anti-TNFRSF17 Recombinant Antibody; Fab Fragment (HPAB-0011-DJB-F(E))	ELISA, FC	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0012-DJB-F(E)	Human Anti-TNFRSF17 Recombinant Antibody; Fab Fragment (HPAB-0012-DJB-F(E))	ELISA, FC	Chimeric (Mouse/Human) Fab

CAT	Product Name	Application	Type
VS-0325-FY2	Human Anti-TNFRSF17 scFv-Fc Chimera (VS-0325-FY2)	FC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC680	Recombinant Anti-TNFRSF17 Vesicular Antibody, EV Displayed (VS-0425-YC680)	ELISA, FC, SPR, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY7376	Anti-TNFRSF17 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0825-YC337	SmartAb™ Recombinant Anti-TNFRSF17 pH-dependent Antibody (VS-0825-YC337)	Inhibition	Human IgG

CAT	Product Name	Application	Type
VS-1025-YC112	Anti-TNFRSF17 Antibody Prodrug, Protease Activated (VS-1025-YC112)	ISZ, Cyt, FuncS

Specific Inquiry

Add to compare

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Anti-Human CTLA4 Recombinant Antibody (TAB-067) (CAT# TAB-067)
Application: WB, FuncS, IF, Neut, ELISA, FC, IP

Human Anti-IGF1R Recombinant Antibody (TAB-199) (CAT# TAB-199)
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC

Anti-EGFR Recombinant Antibody (Nimotuzumab) (CAT# TAB-710)
Application: ELISA, IP, FC, FuncS, Neut, IF, IHC

Humanized Anti-NCAM1 Recombinant Antibody (clone Lorvotuzumab) (CAT# TAB-188)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Anti-Human Integrin alpha 5 beta 1 Recombinant Antibody (Volociximab) (CAT# TAB-077)
Application: ELISA, IHC

Anti-Human CD30 Recombinant Antibody (Iratumumab) (CAT# TAB-144)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Anti-Human IL5RA Recombinant Antibody (TAB-222) (CAT# TAB-222)
Application: WB, FC, IP, ELISA, Neut, FuncS, IF

Anti-Human Met(Onartuzumab) (CAT# TAB-190-F(E))
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Anti-Human PCSK9 Recombinant Antibody (Bococizumab) (CAT# TAB-H10)
Application: WB, FC, IP, ELISA, Neut, FuncS, IF

Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (TAB-153) (CAT# TAB-153)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) (CAT# TAB-707)
Application: WB, FuncS, IF, Neut, ELISA, FC, IP

Anti-Human EGFR Recombinant Antibody (Modotuximab) (CAT# TAB-H49)
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC

Anti-Human DKK1 Recombinant Antibody (BHQ880) (CAT# TAB-214CL)
Application: IHC, ELISA, IB

Human Anti-Human EPCAM Recombinant Antibody (3622W94) (CAT# TAB-235CL)
Application: Cyt, FC

Human Anti-ERBB2 Rcombinant Antibody (TP-083CL) (CAT# TP-083CL)
Application:

Human IgG1, kappa - Isotype Control Antibody (CAT# MOB-0402ZL)
Application: ELISA

Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5) (CAT# PABL-186)
Application: WB, Neut, FuncS

Recombinant Human Anti-IAV HA Antibody (5J8) (CAT# PABL-207)
Application: FuncS

Recombinant Human Anti-RSV Antibody (AM14) (CAT# PABL-321)
Application: WB, ELISA, Neut, FuncS

Anti-Human LAG3 Recombinant Antibody (TSR-033) (CAT# TAB-0367CL)
Application: FC, FuncS, Block

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.