A*02:01/Human Mart-1 (ELAGIGILTV) MHC Tetramer (CAT#: MHC-LC001)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Mart-1-derived peptide of ELAGIGILTV sequence covering 26-35 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in skin 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_B_8_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_B_8_1_val_selected.jpg
Figure 2 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_8_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_8_4_val_selected.jpg
Figure 3 Testis
(Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_5_6.jpg
(Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_5_6.jpg
Figure 4 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120215-MLANA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120215-MLANA
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- Mart-1
- Antigen Species
- Human
- Peptide
- ELAGIGILTV
- Range
- 26-35
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA o "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.
- Alternative Names
- MLANA; melan-A; MART1; MART-1
- Gene ID
- 2315
- UniProt ID
- Q16655
Downloads
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| NABL-096 | Recombinant Anti-human MLANA VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
Customer Reviews and Q&As
Customer Review
Q&As
Long Shelf Life
This pentamer has a longer shelf life than others I've used. Even after extended storage, its effectiveness remains unchanged.
Multiplex Friendly
We are able to run multiplex assays efficiently with this product. It's significantly enhanced the depth of our research.
Detailed Documentation
Comes with very detailed and helpful documentation. It made it easy to troubleshoot and ensure proper usage.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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