A*02:01/Human Mart-1 (ELAGIGILTV) MHC Tetramer
CAT#: MHC-LC001
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Mart-1-derived peptide of ELAGIGILTV sequence covering 26-35 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 High expression in skin 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_B_8_1_val_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_8_4_val_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48662/167996_A_5_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120215-MLANA
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- Mart-1
- Antigen Species
- Human
- Peptide
- ELAGIGILTV
- Range
- 26-35
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA o "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.
- Alternative Names
- MLANA; melan-A; MART1; MART-1
- Gene ID
- 2315
- UniProt ID
- Q16655
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Long Shelf Life
This pentamer has a longer shelf life than others I've used. Even after extended storage, its effectiveness remains unchanged.
Multiplex Friendly
We are able to run multiplex assays efficiently with this product. It's significantly enhanced the depth of our research.
Detailed Documentation
Comes with very detailed and helpful documentation. It made it easy to troubleshoot and ensure proper usage.
Q&As
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Does this MHC Pentamer show lot-to-lot consistency?
A: Researchers have confirmed that lot-to-lot consistency is maintained, with minimal variability affecting experimental outcomes.
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Is the product cost-effective for large-scale research projects?
A: Many researchers find the pricing reasonable for the quality and effectiveness it offers, making it cost-effective for large-scale studies.
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Are control samples required when using this pentamer?
A: Including control samples is recommended to validate the specificity and effectiveness of the pentamer in assays.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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