APC-A*02:01/Human EphA2 (TLADFDPRV) MHC Tetramer (CAT#: MHC-LC146)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of EphA2-derived peptide of TLADFDPRV sequence covering 883-891 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
(Immunofluorescent staining of human cell line A549 shows localization to nuclear speckles, plasma membrane, the Golgi apparatus & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10464/991_D3_3_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (CAPAN-2, PC-3, U-251 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142627-EPHA2
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- EphA2
- Antigen Species
- Human
- Peptide
- TLADFDPRV
- Range
- 883-891
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
- Alternative Names
- EPHA2; EPH receptor A2; ECK; CTPA; ARCC2; CTPP1; CTRCT6
- Gene ID
- 1969
- UniProt ID
- P29317
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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