APC-A*02:01/Human HNRNPK (SLAGGIIGV) MHC Tetramer

CAT#: MHC-LC3870

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HNRNPK of peptide SLAGGIIGV covering 154-162 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 IF staining of human cell line U-251 MG Figure 3 IHC staining of human oral mucosa Figure 4 Kidney Figure 5 Testis Figure 6 Lymph node Figure 7 Cerebral cortex Figure 8 Colon Figure 9 RNA cell line category: Low cell line specificity

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • HNRNPK
  • Antigen Species
  • Human
  • Peptide
  • SLAGGIIGV
  • Range
  • 154-162
  • Conjugate
  • APC

Target

  • Antigen Introduction
  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • HNRNPK; Heterogeneous nuclear ribonucleoprotein K; AUKS; CSBP; TUNP; HNRPK
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