APC-A*02:01/Human MC5R (SVMDPLIYA) MHC Tetramer (CAT#: MHC-LC2934)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human MC5R of peptide SVMDPLIYA covering 288-296 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58088/2008_C5_19_cr5f1ac3a567860_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58088/2008_C5_19_cr5f1ac3a567860_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42365/166023_A_5_6_selected.jpg
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42365/166023_A_5_6_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42365/166023_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42365/166023_B_8_5.jpg
Figure 4 Hippocampus
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42365/166023_B_9_6.jpg
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42365/166023_B_9_6.jpg
Figure 5 Testis
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42365/166023_A_6_6.jpg
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Round or early spermatids Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42365/166023_A_6_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (U-138 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000176136-MC5R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000176136-MC5R
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- MC5R
- Antigen Species
- Human
- Peptide
- SVMDPLIYA
- Range
- 288-296
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
- Alternative Names
- MC5R; Melanocortin receptor 5; MC2
- Gene ID
- 4161
- UniProt ID
- P33032
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2187 | Hi-Affi™ Recombinant Rabbit Anti-MC5R Monoclonal Antibody (DS2187AB) | WB, IHC, FC | IgG |
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