APC-A*02:01/Human PRAME (ALYVDSLFFL) MHC Tetramer (CAT#: MHC-LC182)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of PRAME-derived peptide of ALYVDSLFFL sequence covering 300-309 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68562/1854_A5_4_selected.jpg
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68562/1854_A5_4_selected.jpg
Figure 2 Colon
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45153/160303_A_7_3.jpg
(Glandular cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45153/160303_A_7_3.jpg
Figure 3 Testis
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45153/160303_A_5_6.jpg
(Elongated or late spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Leydig cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45153/160303_A_5_6.jpg
Figure 4 RNA cell line category: Cell line enriched (K-562)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185686-PRAME/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185686-PRAME/subcellular
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- PRAME
- Antigen Species
- Human
- Peptide
- ALYVDSLFFL
- Range
- 300-309
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
- Alternative Names
- PRAME; preferentially expressed antigen in melanoma; MAPE; OIP4; CT130; OIP-4
- Gene ID
- 23532
- UniProt ID
- Q05320
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ScFv Antibodies
IgG Antibodies
Fab Antibodies
MHC Tetramers for Cancer
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1701LY-S(P) | Human Anti-PRAME Recombinant Antibody; scFv Fragment (HPAB-1701LY-S(P)) | ELISA, WB, RIA | Humanized scfv |
| HPAB-1702LY-S(P) | Human Anti-PRAME Recombinant Antibody; scFv Fragment (HPAB-1702LY-S(P)) | ELISA, WB, RIA | Humanized scfv |
| HPAB-1703LY-S(P) | Human Anti-PRAME Recombinant Antibody; scFv Fragment (HPAB-1703LY-S(P)) | ELISA, WB, RIA | Humanized scfv |
| HPAB-1704LY-S(P) | Human Anti-PRAME Recombinant Antibody; scFv Fragment (HPAB-1704LY-S(P)) | ELISA, WB, RIA | Humanized scfv |
| HPAB-1705LY-S(P) | Human Anti-PRAME Recombinant Antibody; scFv Fragment (HPAB-1705LY-S(P)) | ELISA, WB, RIA | Humanized scfv |
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For Research Use Only. Not For Clinical Use.
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