APC-B*40:02/Human INCENP (REFSKEPEL) MHC Tetramer
CAT#: MHC-LC840
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of INCENP-derived peptide of REFSKEPEL covering 47-55 and B*40:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, kinetochore & midbody.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/70550/1592_F10_3_selected.jpg
Normal Tissue
Figure 2 Bone marrow
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13292/31224_B_6_4_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: Medium Intensity: Strong Quantity: <25% Enterocytes - Goblet cells Staining: Medium Intensity: Strong Quantity: <25% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13292/31224_A_9_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Pachytene spermatocytes Staining: Medium Intensity: Strong Quantity: <25% Preleptotene spermatocytes Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13292/31224_A_6_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13292/31224_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000149503-INCENP
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Specifications
- Allele
- B*40:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- INCENP
- Antigen Species
- Human
- Peptide
- REFSKEPEL
- Range
- 47-55
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis.
- Alternative Names
- INCENP; inner centromere protein
- Gene ID
- 3619
- UniProt ID
- Q9NQS7
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "INCENP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2122MZ | Recombinant Mouse Anti-Human INCENP Antibody (clone 69-328) | ICC, IF, IHC-P | Mouse antibody |
| VS3-QX604 | Mouse Anti-INCENP Recombinant Antibody (clone 3D2) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-WK147 | Mouse Anti-INCENP Recombinant Antibody (clone G9-D2) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC839 | PE-B*40:02/Human INCENP (REFSKEPEL) MHC Tetramer | FCM | |
| MHC-LC841 | BV421-B*40:02/Human INCENP (REFSKEPEL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1828 | Rabbit Anti-INCENP Recombinant Antibody (clone DS1828AB) | WB, ICC | Rabbit IgG |
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