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APC-B*40:02/Human INCENP (REFSKEPEL) MHC Tetramer (CAT#: MHC-LC840)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of INCENP-derived peptide of REFSKEPEL covering 47-55 and B*40:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, kinetochore & midbody.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70550/1592_F10_3_selected.jpg
Normal Tissue
Figure 2 Bone marrow
Figure 2 Bone marrow
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13292/31224_B_6_4_val_selected.jpg
Figure 3 Colon
Figure 3 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: Medium Intensity: Strong Quantity: <25% Enterocytes - Goblet cells Staining: Medium Intensity: Strong Quantity: <25% Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13292/31224_A_9_3.jpg
Figure 4 Testis
Figure 4 Testis
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Pachytene spermatocytes Staining: Medium Intensity: Strong Quantity: <25% Preleptotene spermatocytes Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13292/31224_A_6_6.jpg
Figure 5 Lymph node
Figure 5 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13292/31224_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000149503-INCENP

Specifications

  • Allele
  • B*40:02
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • INCENP
  • Antigen Species
  • Human
  • Peptide
  • REFSKEPEL
  • Range
  • 47-55
  • Conjugate
  • APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis.
  • Alternative Names
  • INCENP; inner centromere protein

Downloads

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See other products for "INCENP"

Recombinant Antibody

CAT Product Name Application Type
MOB-2122MZ Recombinant Mouse Anti-Human INCENP Antibody (clone 69-328) ICC/IF, IHC-P Mouse antibody
VS3-QX604 Mouse Anti-INCENP Recombinant Antibody (clone 3D2) WB, IHC, ICC, FC, ELISA Mouse IgG1
VS3-WK147 Mouse Anti-INCENP Recombinant Antibody (clone G9-D2) WB, ELISA Mouse IgG1

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC839 PE-B*40:02/Human INCENP (REFSKEPEL) MHC Tetramer FCM
MHC-LC841 BV421-B*40:02/Human INCENP (REFSKEPEL) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1828 Rabbit Anti-INCENP Recombinant Antibody (clone DS1828AB) WB, ICC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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