APC-H-2Db/LCMV gp276-286 (SGVENPGGYCL) MHC Tetramer
CAT#: MHC-LC294
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of LCMV-derived peptide of SGVENPGGYCL sequence covering 276-286 and H-2Db molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2Db
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- LCMV gp276-286
- Antigen Species
- LCMV
- Peptide
- SGVENPGGYCL
- Range
- 276-286
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae. The name was coined by Charles Armstrong in 1934.
- Alternative Names
- LCMV GP1; Lymphocytic choriomeningitis virus Glycoprotein 1
- Gene ID
- 1491875
- UniProt ID
- P26804
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Great for Mouse T Cells
We used this APC-conjugated tetramer to analyze mouse CD8 T cells specific to the LCMV gp276-286 epitope. The staining quality was excellent, and it allowed us to visualize the specific T cell response to the virus in our murine model.
Clear Flow Cytometry Results
The H-2Db tetramer complex functioned exactly as described for detecting cells recognizing the SGVENPGGYCL peptide sequence. The APC label provided a strong signal in flow cytometry, making the analysis of individual antigen-specific T cells straightforward and reproducible.
Q&As
-
Which peptide sequence is presented by this MHC tetramer?
A: This tetramer presents the LCMV-derived peptide with the sequence SGVENPGGYCL. It corresponds to the LCMV gp276-286 region and is presented by the mouse H-2Db molecule, allowing for the detection of specific CD8 T cells.
-
Can this product be used to detect mouse T cells?
A: Yes, this APC-conjugated tetramer is specifically designed to recognize mouse CD8 T cells. It is composed of the H-2Db molecule complexed with the LCMV peptide, making it suitable for analyzing individual antigen-specific T cells in murine models.
View the frequently asked questions answered by Creative Biolabs Support.
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Datasheet
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See other products for "LCMV GP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC284 | BV421-H-2Db/LCMV gp33 (KAVYNFATC) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC293 | PE-H-2Db/LCMV gp276-286 (SGVENPGGYCL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC295 | BV421-H-2Db/LCMV gp276-286 (SGVENPGGYCL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC296 | BV421-H-2Kb/LCMV gp34-41 (AVYNFATC) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC297 | PE-H-2Kb/LCMV gp34-43 (AVYNFATCGI) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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