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    APC-H-2Kd/Human JAK1 (SYFPEITHI) MHC Tetramer (CAT#: MHC-LC207)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of JAK1-derived peptide of SYFPEITHI sequence covering 367-375 and H-2Kd molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

    Specific Inquiry
    • Size:
    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human tonsil
    Figure 1 IHC staining of human tonsil
    (Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in non-germinal center cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/13088/33500_A_6_8_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Neuronal cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/13088/33500_B_8_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Peripheral nerve/ganglion
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/13088/33500_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Cholangiocytes
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/13088/33500_A_7_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in tubules
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/13088/33500_A_8_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Leydig cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/13088/33500_A_4_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/13088/33500_A_9_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Cell line enhanced (ASC diff)
    Figure 8 RNA cell line category: Cell line enhanced (ASC diff)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162434-JAK1

    Specifications

    • Allele
    • H-2Kd
    • Class
    • Class I
    • MHC Species
    • Mouse
    • Antigen
    • JAK1
    • Antigen Species
    • Human
    • Peptide
    • SYFPEITHI
    • Range
    • 367-375
    • Conjugate
    • APC
    • Application
    • FCM

    Target

    • Antigen Introduction
    • This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants.
    • Alternative Names
    • JAK1; Janus kinase 1; JTK3; JAK1A; JAK1B

    Related Resources

    • Related Diseases

    Downloads

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    Please select product type
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    CAT Product Name Application Type
    MHC-LC206 PE-H-2Kd/Human JAK1 (SYFPEITHI) MHC Tetramer FCM

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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