Anti-α-FR Antibody-Cytokine Fusion Protein, IL2-scFv (MOV19)

Name: Anti-α-FR Antibody-Cytokine Fusion Protein, IL2-scFv (MOV19)
SKU: ACFP-SH052
Rating: 5 (1 reviews)

CAT#: ACFP-SH052

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-α-FR scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the α-FR as well as the biological activity of IL2. This construct might improve the tissue penetration and distribution of the fusion protein within the tumor, reduce its immunogenicity, and avoid the toxicity related to the systemic administration of IL2. This immunocytokine was designed for treating ovarian cancer.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HeLa

Immunofluorescent staining of human cell line HeLa shows localization to nuclear membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77030/1659_B3_2_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HeLa, RPTEC TERT1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110195-FOLR1

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Specifications

Target
α-FR

Molecule Class
IL2-scFv

Species Reactivity
Human

Expression Host
CHO

Clone
MOV19

Related Disease
Ovarian cancer

Cytokine 1
IL2

Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.

Cytokine 1 Species
Human

Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Alternative Names
FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor; adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18

Gene ID
2348

UniProt ID
P15328

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Datasheet

Datasheet - ACFP-SH052.pdf

MSDS

MSDS - ACFP-SH052.pdf

COA

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