This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-αvβ integrin receptor IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the αvβ integrin receptor as well as the biological activity of IL2. DI-17E6 shows potency and selectivity at the isolated receptor and cellular level (e.g. receptor binding, cell adhesion and cell migration studies). DI-17E6 shows tumor-growth inhibiting activity in vitro and in animal models (e.g. experimental tumor nude mouse, SCID mouse/human skin chimera). This immunocytokine was designed for treating tumor.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-076 | Anti-Human CD51 Recombinant Antibody (Intetumumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H01 | Anti-Human ITGAV Recombinant Antibody (Abituzumab) | Inhib, Agonist | IgG2 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6) | WB, ELISA, FuncS | Mouse IgG |
MOB-0242CT | Recombinant Mouse anti-Human ITGAV Monoclonal antibody (24D3) | FC, IHC-Fr, PP | |
MRO-0852-CN | Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (CBACN-313) | WB, FC | Rabbit IgG |
HPAB-1767-FY | Human Anti-ITGAV Recombinant Antibody (clone 12G3) | ADCC | Humanized IgG |
VS-0423-XY25 | Human Anti-ITGAV Recombinant Antibody (clone Bc-20) | ELISA, IF | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
HPAB-1767-FY-F(E) | Human Anti-ITGAV Recombinant Antibody (clone 12G3); scFv Fragment | Cyt, ELISA | Humanized scFv |
HPAB-1768-FY-F(E) | Human Anti-ITGAV Recombinant Antibody (clone 3F2); scFv Fragment | Cyt, ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
HPAB-1767-FY-S(P) | Human Anti-ITGAV Recombinant Antibody (clone 12G3); Fab Fragment | Cyt, ELISA | Humanized Fab |
HPAB-1768-FY-S(P) | Human Anti-ITGAV Recombinant Antibody (clone 3F2); Fab Fragment | Cyt, ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-191-S (P) | Recombinant Mouse Anti-αVβ3 Ectodomain Antibody scFv Fragment (17E6) | Neut, FuncS | scFv |
PABX-191-F (E) | Recombinant Mouse Anti-αVβ3 Ectodomain Antibody Fab Fragment (17E6) | Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1537CQ | Recombinant Mouse Anti-ITGAV Antibody (272-17E6) | Inhib, ICC/IF, BL, FC, ELISA, IP | IgG1 |
NEUT-1577CQ | Recombinant Mouse Anti-ITGAV Antibody (13C2) | FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion | IgG1, κ |
NEUT-1578CQ | Recombinant Mouse Anti-ITGAV Antibody (NKI-M9) | FC, IF, ELISA, BL, IP | IgG2a, κ |
NEUT-1579CQ | Recombinant Mouse Anti-ITGAV Antibody (10D5) | IP, FC, BL | IgG2a |
NEUT-1580CQ | Recombinant Mouse Anti-ITGAV Antibody (27.1) | ICC/IF, FC, IP, IHC-Fr, BL | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1582CQ | Recombinant Rat Anti-Itgav Antibody (RMV-7) | FC, FuncS, IP, Neut | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1880 | Hi-Affi™ Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (DS1880AB) | WB, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-076 | Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Intetumumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-H01 | Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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