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    Anti-αvβ integrin receptor Antibody-Cytokine Fusion Protein, IgG-IL2 (CAT#: ACFP-SH136)

    This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-αvβ integrin receptor IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the αvβ integrin receptor as well as the biological activity of IL2. The antibody can enhance the activity of cytotoxic drug based therapies, leading to more anti-tumor activity in vivo. The antibody causes the depolymerization of focal adhesions dependent on αvβ3 and αvB5. These signalling complexes assemble after integrin ligation. They organize communication with growth, survival and motility pathways, and their destruction can trigger apoptosis. Thus antibody uses a combination of mechanochemical and biochemical effects to affect endothelia and to increase stress on tumor cells. This immunocytokine was designed for treating tumor.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to cytosol & focal adhesion sites.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/if_selected.jpg
    Figure 2 IHC staining of human placenta
    Figure 2 IHC staining of human placenta
    (Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/ihc_selected.jpg
    Figure 3 IHC staining of human urinary bladder
    Figure 3 IHC staining of human urinary bladder
    (Immunohistochemical staining of human urinary bladder shows strong membranous positivity in urothelial cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/ihc_selected.jpg
    Figure 4 IF staining of human cell line U-2 OS
    Figure 4 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & focal adhesion sites.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/10_E3_1_blue_red_green.jpg
    Figure 5 IF staining of human cell line U-251 MG
    Figure 5 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & focal adhesion sites.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/15_E3_1_blue_red_green.jpg
    Normal Tissue
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_B_8_5.jpg
    Figure 7 Colon
    Figure 7 Colon
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_9_3.jpg
    Figure 8 Liver
    Figure 8 Liver
    (Cholangiocytes
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_9_4.jpg
    Figure 9 Placenta
    Figure 9 Placenta
    (Cytotrophoblasts
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Endothelial cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Syncytiotrophoblasts - cell body
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Syncytiotrophoblasts - microvilli
    Staining: High
    Intensity: Strong)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_2_7.jpg
    RNA Expression
    Figure 10 RNA cell line category: Cell line enhanced (RT4, SuSa)
    Figure 10 RNA cell line category: Cell line enhanced (RT4, SuSa)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138448-ITGAV

    Specifications

    • Target
    • αvβ integrin receptor
    • Molecule Class
    • L Kappa; IgG2-IL2
    • Species Reactivity
    • Human
    • Expression Host
    • CHO
    • Clone
    • DI-17E6
    • Related Disease
    • Tumor
    • Cytokine 1
    • IL2
    • Cytokines 1 Description
    • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
    • Cytokine 1 Species
    • Human
    • Applications
    • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

    Target

    • Alternative Names
    • CD51; MSK8; VNRA; VTNR

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    TAB-076 Anti-Human CD51 Recombinant Antibody (TAB-076) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

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