Human Anti-ABCB11 Recombinant Antibody (clone Tweed); scFv Fragment (CAT#: HPAB-0192-CN-S(P))
Antibody Tweed is an isolated monoclonal antibody that specifically binds to an extracellular epitope on the N-terminal half of BSEP and modulates BSEP function. Antibody Tweed recognizes an epitope present on the C-terminal half of BSEP,
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/if_selected.jpg
Figure 2 High expression in liver
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_9_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_9_4.jpg
Figure 3 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_4_6.jpg
Figure 4 RNA cell line category: Cell line enhanced (NB-4, RT4, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073734-ABCB11
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073734-ABCB11
Specifications
- Host Species
- Human
- Type
- Human scFv
- Specificity
- Human ABCB11
- Species Reactivity
- Human, Rat
- Clone
- Tweed
- Applications
- WB, FC, IF
- Related Disease
- Cancer such as hepatocellular carcinoma and hepatoblastoma
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11; Progressive Familial Intrahepatic Cholestasis 2; ATP-Binding Cassette Sub-Family B Member 11; BSEP; ABC Member 16, MDR/TAP Subfamily; Bile Salt Export Pump; Sister P-Glycoprotein; MDR/TAP Subfamily; ABC Member 16; EC 3.6.3.44; EC 3.6.3; PFIC-2; ABC16; BRIC2; PFIC2; PGY4; SPGP
- Gene ID
- 8647
- UniProt ID
- O95342
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone Tweed"
See other products for "ABCB11"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2146z | Mouse Anti-ABCB11 Recombinant Antibody (clone 38B10) | WB, ELISA, IF, IHC, IP | Mouse IgG2a, κ |
| HPAB-0190-CN | Human Anti-ABCB11 Recombinant Antibody (clone Batist) | WB, FC, IF | Human IgG1 |
| HPAB-0191-CN | Human Anti-ABCB11 Recombinant Antibody (clone Malimo) | WB, FC, IF | Human IgG1 |
| HPAB-0192-CN | Human Anti-ABCB11 Recombinant Antibody (clone Tweed) | WB, FC, IF | Human IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0010 | Hi-Affi™ Rabbit Anti-ABCB11 Recombinant Antibody (clone DS10AB) | WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0190-CN-S(P) | Human Anti-ABCB11 Recombinant Antibody (clone Batist); scFv Fragment | WB, FC, IF | Human scFv |
| HPAB-0191-CN-S(P) | Human Anti-ABCB11 Recombinant Antibody (clone Malimo); scFv Fragment | WB, FC, IF | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0190-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Batist); Fab Fragment | WB, FC, IF | Human Fab |
| HPAB-0191-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Malimo); Fab Fragment | WB, FC, IF | Human Fab |
| HPAB-0192-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Tweed); Fab Fragment | WB, FC, IF | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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