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ACVRL1
Anti-Human ACVRL1 Recombinant Antibody (PF-03446962)

Anti-Human ACVRL1 Recombinant Antibody (PF-03446962) (CAT#: TAB-013CL)

Recombinant Human monoclonal antibody expressed in CHO binding to Human ACVRL1. PF-03446962, a fully-human monoclonal antibody against transforming growth-factor β (TGFβ) receptor ALK1, in pre-treated patients with urothelial cancer: an open label, single-group, phase 2 trial.

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Tested Data
Gene Expression
Datasheet
MSDS
COA

SDS-PAGE

Figure 1 Anti-Human ACVRL1 Recombinant Antibody (TAB-013CL) in SDS-PAGE

Figure 1 Anti-Human ACVRL1 Recombinant Antibody (TAB-013CL) in SDS-PAGE

Lane 1: Non-reducing (2.0 µg) Lane 2: Reducing (1.0 µg)

Normal Tissue

Figure 1 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong granular cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/ihc_selected.jpg

Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_B_7_5.jpg

Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_7_3.jpg

Figure 4 Gallbladder
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_5_4.jpg

Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_8_5.jpg

Figure 6 Testis
(Elongated or late spermatids Staining: High Intensity: Strong Quantity:>75% Leydig cells Staining: Low Intensity: Weak Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_6_6.jpg

Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7041/21213_A_9_8.jpg

RNA Expression

Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139567-ACVRL1

Datasheet

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Host Species
Human

Derivation
Human

Type
Antibody

Species Reactivity
Human

Related Disease
Urothelial Cancer

Product Property

Purity
>95% as determined by analysis by RP-HPLC

Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Target

Alternative Names
ACVRL1; activin A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK

Gene ID
94

UniProt ID
P37023

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Rabbit Monoclonal Antibody Human Antibody Fab Fragment Antibody ADCC Enhanced Antibody Recombinant Antibody scFv Fragment Antibody

CAT	Product Name	Application	Type
MOR-0065	Hi-Affi™ Rabbit Anti-ACVRL1 Recombinant Antibody (clone DS65AB)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
TAB-003ML	Anti-Human ACVRL1 Recombinant Antibody (Ascrinvacumab)	ELISA, IHC, FC, IP, IF, Inhib	IgG2, κ

CAT	Product Name	Application	Type
HPAB-0136-CN-F(E)	Human Anti-ACVRL1 Recombinant Antibody (clone MOR05444); Fab Fragment	ELISA, IHC	Human Fab
HPAB-0137-CN-F(E)	Human Anti-ACVRL1 Recombinant Antibody (clone MOR05377); Fab Fragment	ELISA, IHC	Human Fab
HPAB-J0024-YC-F(E)	Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0024-YC-F(E))	ELISA, FC, WB	Human Fab
HPAB-J0025-YC-F(E)	Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0025-YC-F(E))	ELISA, FC, WB	Human Fab
HPAB-J0026-YC-F(E)	Human Anti-ACVRL1 Recombinant Antibody; Fab Fragment (HPAB-J0026-YC-F(E))	ELISA, FC, WB, Inhib, FuncS	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-003ML	Afuco™ Anti-ACVRL1 ADCC Recombinant Antibody (Ascrinvacumab), ADCC Enhanced	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-J0024-YC	Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0024-YC)	ELISA, FC, WB	Human IgG1
HPAB-J0025-YC	Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0025-YC)	ELISA, FC, WB	Human IgG
HPAB-J0026-YC	Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0026-YC)	ELISA, FC, WB, Inhib, FuncS	Human IgG1
HPAB-J0027-YC	Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0027-YC)	ELISA	Human IgG
HPAB-J0028-YC	Human Anti-ACVRL1 Recombinant Antibody (HPAB-J0028-YC)	ELISA, FC, WB	Human IgG

CAT	Product Name	Application	Type
HPAB-J0024-YC-S(P)	Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0024-YC-S(P))	ELISA, FC, WB	Human scFv
HPAB-J0025-YC-S(P)	Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0025-YC-S(P))	ELISA, FC, WB	Human scFv
HPAB-J0026-YC-S(P)	Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0026-YC-S(P))	ELISA, FC, WB, Inhib, FuncS	Human scFv
HPAB-J0027-YC-S(P)	Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0027-YC-S(P))	ELISA	Human scFv
HPAB-J0028-YC-S(P)	Human Anti-ACVRL1 Recombinant Antibody; scFv Fragment (HPAB-J0028-YC-S(P))	ELISA, FC, WB	Human scFv

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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