Rat Anti-AChR Recombinant Antibody (clone mAb198) (CAT#: PABZ-007)
Recombinant Rat Antibody (mAb198) is capable of binding to AChR. This antibody binds to a region on the extracellular surface of the a subunit of the AChR named the main immunogenic region (MIR).
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Figure 1 Immunoblots of short fusion proteins.
Equivalent amounts of fusion proteins Tax2 (left), X8 (center) and CaX2 (right) were electrophoresed and transferred by diffusion as described (8). Replicates were probed with control mAb 118 (anti+ chain of Torpedo nAChR), anti-MIR mAbs 42, 37, 6, and 198, and a-BTX. The molecular masses of the fusion proteins are approximately 30 kDa; CaX2 migrates with an apparent mass of 20 kDa.
Barkas, T., Gabriel, J. M., Mauron, A., Hughes, G. J., Roth, B., Alliod, C., ... & Ballivet, M. (1988). Monoclonal antibodies to the main immunogenic region of the nicotinic acetylcholine receptor bind to residues 61-76 of the alpha subunit. Journal of Biological Chemistry, 263(12), 5916-5920.
Figure 2 ELISA tests using X4 and X8.
Binding of control mAb 118 (boxes) and anti-MIR mAbs 6 (open circles), 37 (open triangles), 42 (closed triangles), and 198 (closed circles) to X4 (left) and X8 (right) was tested by ELISA as described under "Materials and Methods." Results shown are the mean and standard error or three separate determinations.
Barkas, T., Gabriel, J. M., Mauron, A., Hughes, G. J., Roth, B., Alliod, C., ... & Ballivet, M. (1988). Monoclonal antibodies to the main immunogenic region of the nicotinic acetylcholine receptor bind to residues 61-76 of the alpha subunit. Journal of Biological Chemistry, 263(12), 5916-5920.
Specifications
- Immunogen
- Human Acetylcholine receptor
- Host Species
- Rat
- Derivation
- Rat
- Type
- Rat IgG
- Specificity
- AChR
- Species Reactivity
- Human
- Clone
- mAb198
- Applications
- WB, ELISA
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Acetylcholine receptor; AChR
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-33-F(E) | Recombinant Human Anti-AChR Antibody Fab Fragment | IF, ELISA, FuncS | Fab |
| PFBC-007 | Rat Anti-AChR Recombinant Antibody (clone mAb192); Fab Fragment | WB, FuncS | Rat IgG2b, κ |
| PFBZ-007 | Rat Anti-AChR Recombinant Antibody (clone mAb198); Fab Fragment | WB, ELISA | Rat IgG |
| FAMAB-0223-YC-F(E) | Rat Anti-AChR Recombinant Antibody (clone mAb 192); Fab Fragment | FuncS | Rat Fab |
| FAMAB-0001WJ-F(E) | Human Anti-AChR Recombinant Antibody (clone 587); Fab Fragment | RIA, IP, IF | Human Fab |
Customer Reviews and Q&As
Customer Review
Q&As
Easy to Use
The handling instructions and datasheet that were included made it simple to use this antibody in our studies and prevented any problems.
Consistent Quality
This antibody has been a constant order for us over a number of batches, so we know it will work as intended in experiments.
Robust Performance
This antibody performs well under a variety of experimental settings, making it a dependable option for studies.
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