The anti-AChR antibody target acetylcholine receptor of which the high-level re-expression can occur after birth following denervation, including denervating neuromuscular diseases. The antibody can be used in the treatment of rhabdomyosarcoma.
Figure 1 Immortalized thymic B cell clones produce striational antibodies.
Monkey muscle tissue was stained by immunofluorescence with culture supernatants (non-concentrated) of immortalized B cell clones.
Vrolix, K., Fraussen, J., Molenaar, P. C., Losen, M., Somers, V., Stinissen, P., ... & Martinez-Martinez, P. (2010). The auto-antigen repertoire in myasthenia gravis. Autoimmunity, 43(5-6), 380-400.
Figure 2 Immortalized B cell clones produce anti-human AChR antibodies.
Specificity of immortalized B cell clones against human AChR was tested by RIA using AChR
isolated from the TE 671 cell line.
Vrolix, K., Fraussen, J., Molenaar, P. C., Losen, M., Somers, V., Stinissen, P., ... & Martinez-Martinez, P. (2010). The auto-antigen repertoire in myasthenia gravis. Autoimmunity, 43(5-6), 380-400.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-33-S(P) | Recombinant Anti-AChR Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
MHH-33-S(P) | Recombinant Human Anti-AChR Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
FAMAB-0001WJ-S(P) | Human Anti-AChR Recombinant Antibody (clone 587); scFv Fragment | RIA, IP, IF | Human scFv |
FAMAB-0002WJ-S(P) | Human Anti-AChR Recombinant Antibody (clone 637); scFv Fragment | RIA, IP, IF | Human scFv |
FAMAB-0029WJ-S(P) | Human Anti-AChR Recombinant Antibody (clone MH6); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-33 | Recombinant Human Anti-AChR Antibody | ELISA, WB, IP, FuncS | IgG |
PABC-007 | Rat Anti-AChR Recombinant Antibody (clone mAb192) | WB, FuncS | Rat IgG2b, κ |
PABZ-007 | Rat Anti-AChR Recombinant Antibody (clone mAb198) | WB, ELISA | Rat IgG |
FAMAB-0223YC | Rat Anti-AChR Recombinant Antibody (clone mAb 192) | FuncS | Rat IgG2b |
FAMAB-0224YC | Rat Anti-AChR Recombinant Antibody (clone mAb 195) | FuncS | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-33-F(E) | Recombinant Human Anti-AChR Antibody Fab Fragment | IF, ELISA, FuncS | Fab |
PFBC-007 | Rat Anti-AChR Recombinant Antibody (clone mAb192); Fab Fragment | WB, FuncS | Rat IgG2b, κ |
FAMAB-0223-YC-F(E) | Rat Anti-AChR Recombinant Antibody (clone mAb 192); Fab Fragment | FuncS | Rat Fab |
FAMAB-0224-YC-F(E) | Rat Anti-AChR Recombinant Antibody (clone mAb 195); Fab Fragment | FuncS | Rat Fab |
FAMAB-0001WJ-F(E) | Human Anti-AChR Recombinant Antibody (clone 587); Fab Fragment | RIA, IP, IF | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0636CLV | Anti-Human AChR Recombinant Antibody (P90-131) | WB | Fully Human antibody |
TAB-0638CLV | Human Anti-AChR Recombinant Antibody (TAB-0638CLV) | Dot, FuncS, IF | Human IgG1 |
TAB-0639CLV | Human Anti-AChR Recombinant Antibody (TAB-0639CLV) | RIA, IF | Human IgG |
TAB-0638CLV-S(P) | Human Anti-AChR Recombinant Antibody; scFv Fragment (TAB-0638CLV-S(P)) | ELISA | Human scFv |
TAB-0639CLV-S(P) | Human Anti-AChR Recombinant Antibody; scFv Fragment (TAB-0639CLV-S(P)) | ELISA | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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