Anti-Human ADAM17 Recombinant Antibody
CAT#: TAB-015CL
Recombinant Human monoclonal antibody expressed in CHO binding to Human ADAM17. Anti-TACE (ADAM17) antibodiess are disclosed that for the first time in the art are capable of binding to TACE, of acting as antagonists of one or more its biological activities, in particular by binding to TACE in a cross domain binding mode in which residues in both the catalytic domain and in the cysteine rich/disintegrin domains (Dis-Cys) are involved in antibody binding to TACE, helping to improve the specificity of the antibody binding and/or helping to improve inhibition of TACE biological activity. The therapeutic uses of the antibodiess, in particular for the treatment of cancer are disclosed.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/51575/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows membranous and cytoplasmic positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_7_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_7_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_4_6.jpg
Normal Tissue
Figure 9 Placenta
Trophoblastic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_2_7.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_9_8.jpg
RNA Expression
Figure 11 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000151694-ADAM17
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- Store at –20 or -70°C upon receipt. Divide antibody into aliquots prior usage and avoid multiple freeze-thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-38 | Recombinant Anti-human ADAM17 Antibody | ELISA, WB, FC, FuncS | IgG |
| MHH-38 | Recombinant Human Anti-human ADAM17 Antibody | ELISA, IP, FuncS | IgG |
| MOB-0437MZ | Mouse Anti-ADAM17 Recombinant Antibody (clone 1F6) | FC, IF, IHC-P, WB | Mouse IgG |
| ZG-0529J | Rabbit Anti-ADAM17 Recombinant Antibody (clone 5A1) | ELISA, IF | Rabbit IgG |
| VS3-FY245 | Recombinant Mouse Anti-ADAM17 Antibody (clone 7A6B2) | ELISA, WB, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-38-F(E) | Recombinant Anti-human ADAM17 Antibody Fab Fragment | ELISA, WB, FuncS | Fab |
| MHH-38-F(E) | Recombinant Human Anti-human ADAM17 Antibody Fab Fragment | ELISA, WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-38-S(P) | Recombinant Anti-human ADAM17 Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| MHH-38-S(P) | Recombinant Human Anti-human ADAM17 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0444CL | Anti-Human ADAM17 Recombinant Antibody (ml022C3) | ELISA, Inhib, FuncS | |
| TAB-0444CL-S(P) | Anti-Human ADAM17 Recombinant Antibody scFv Fragment (ml022C3) | ELISA, Inhib, FuncS | |
| TAB-0444CL-F(E) | Anti-Human ADAM17 Recombinant Antibody Fab Fragment (ml022C3) | ELISA, Inhib, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0445CL | Anti-Human ADAM17 Recombinant Antibody (cl022C3) | ELISA, Inhib, FuncS | Chimeric (mouse/human) |
| TAB-0445CL-S(P) | Anti-Human ADAM17 Recombinant Antibody scFv Fragment (cl022C3) | ELISA, Inhib, FuncS | Chimeric (mouse/human) |
| TAB-0445CL-F(E) | Anti-Human ADAM17 Recombinant Antibody Fab Fragment (cl022C3) | ELISA, Inhib, FuncS | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0446CL | Anti-Human ADAM17 Recombinant Antibody (hzl022C3) | ELISA, Inhib, FuncS | Humanized Antibody |
| TAB-0446CL-S(P) | Anti-Human ADAM17 Recombinant Antibody scFv Fragment (hzl022C3) | ELISA, Inhib, FuncS | Humanized Antibody |
| TAB-0446CL-F(E) | Anti-Human ADAM17 Recombinant Antibody Fab Fragment (hzl022C3) | ELISA, Inhib, FuncS | Humanized Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0447CL | Anti-Human ADAM17 Recombinant Antibody (hl022C3) | ELISA, Inhib, FuncS | Human antibody |
| TAB-0447CL-S(P) | Anti-Human ADAM17 Recombinant Antibody scFv Fragment (hl022C3) | ELISA, Inhib, FuncS | Human antibody |
| TAB-0447CL-F(E) | Anti-Human ADAM17 Recombinant Antibody Fab Fragment (hl022C3) | ELISA, Inhib, FuncS | Human antibody |
| TAB-0669CLV | Anti-Human ADAM17 Recombinant Antibody (D1(A12)) | ELISA, PK, Inhib, IHC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0070 | Hi-Affi™ Rabbit Anti-ADAM17 Recombinant Antibody (clone DS70AB) | WB, IF, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0393 | PE-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer | FCM, IHC | |
| MHC-CN0394 | APC-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer | FCM, IHC | |
| MHC-CN0395 | FITC-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer | FCM, IHC | |
| MHC-CN0396 | A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer | FCM, IHC | |
| MHC-YF732 | A*02:01/Human TACE (YLIELIDRV) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC601 | AbPlus™ Anti-ADAM17 Magnetic Beads (VS-0724-YC601) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY41 | Anti-ADAM17 Immunohistochemistry Kit | IHC | |
| VS-0525-XY149 | Anti-Human ADAM17 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC313 | Recombinant Anti-ADAM17 Vesicular Antibody, EV Displayed (VS-0425-YC313) | ELISA, FC, Cell-uptake |
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