Anti-Human ADAMTS4 Recombinant Antibody (7E8.1E3) (CAT#: TAB-0677CLV)
The anti-ADAMTS4 antibody 7E8.1E3 targets ADAMTS4 that is kind of aggrecanases of which the activities can result in the degradation of the cartilage matrix. By inhibiting ADAMTS4 and thereby reducing the breakdown of extracellular matrix aggrecan in cartilage and other tissues, 7E8.1E3 can be used in the treatment of diseases of cartilage.
Specific Inquiry
Inhib
Figure 1 ADAMTS-4 and ADAMTS-5 mAbs specifically bind to and potently inhibit aggrecanase activity.
Functional potency of ADAMTS-4 mAbs and non-selective small molecule (GSK579149) is quantified vs isotype controls (not shown) by measuring percent inhibition of selective aggrecanase-mediated ARGS neoepitope formation from purified bovine aggrecan substrate.
Larkin, J., Lohr, T. A., Elefante, L., Shearin, J., Matico, R., Su, J. L., ... & Tran, P. B. (2015). Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis and cartilage, 23(8), 1254-1266.
Specifications
- Immunogen
- ADAMTS4, ADAMTS5
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Cross-react with rat ADAMTS4
- Clone
- 7E8.1E3
- Applications
- Inhib
- Related Disease
- Diseases of cartilage
Applications
- Application Notes
- The ADAMTS4 antibody has been reported in applications of Inhibition.
Target
- Alternative Names
- ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADMP-1; EC 3.4.24.82; KIAA0688; A disintegrin and metalloproteinase with thrombospondin motifs 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospo
- Gene ID
- 9507
- UniProt ID
- O75173
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0676CLV | Anti-Human ADAMTS4 Recombinant Antibody (7C7.1H1) | Inhib |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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