Anti-Human ADAMTS4 Recombinant Antibody (7E8.1E3) (CAT#: TAB-0677CLV)

The anti-ADAMTS4 antibody 7E8.1E3 targets ADAMTS4 that is kind of aggrecanases of which the activities can result in the degradation of the cartilage matrix. By inhibiting ADAMTS4 and thereby reducing the breakdown of extracellular matrix aggrecan in cartilage and other tissues, 7E8.1E3 can be used in the treatment of diseases of cartilage.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 ADAMTS-4 and ADAMTS-5 mAbs specifically bind to and potently inhibit aggrecanase activity.

Figure 1 ADAMTS-4 and ADAMTS-5 mAbs specifically bind to and potently inhibit aggrecanase activity.

Functional potency of ADAMTS-4 mAbs and non-selective small molecule (GSK579149) is quantified vs isotype controls (not shown) by measuring percent inhibition of selective aggrecanase-mediated ARGS neoepitope formation from purified bovine aggrecan substrate.

Larkin, J., Lohr, T. A., Elefante, L., Shearin, J., Matico, R., Su, J. L., ... & Tran, P. B. (2015). Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis and cartilage, 23(8), 1254-1266.


  • Immunogen
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Species Reactivity
  • Cross-react with rat ADAMTS4
  • Clone
  • 7E8.1E3
  • Applications
  • Inhib
  • Related Disease
  • Diseases of cartilage


  • Application Notes
  • The ADAMTS4 antibody has been reported in applications of Inhibition.


  • Alternative Names
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADMP-1; EC; KIAA0688; A disintegrin and metalloproteinase with thrombospondin motifs 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospo

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.


Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 7E8.1E3"

See other products for "ADAMTS4"

Mouse Antibody

CAT Product Name Application Type
TAB-0676CLV Anti-Human ADAMTS4 Recombinant Antibody (7C7.1H1) Inhib

Recombinant Antibody

Neutralizing Antibody

scFv Fragment Antibody

Fab Fragment Antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-0677CLV. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0

    Go to compare