Recombinant Human Antibody (26-2F) is capable of binding to ANG, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ANG mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ANG mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 IHC detection of human and mouse ANG in normal and cancer tissues.
Human ANG was detected by 26-2F, Mouse ANG was detected by an affinity-purified polyclonal antibody.
Li, S., & Hu, G. F. (2010). Angiogenin-mediated rRNA transcription in cancer and neurodegeneration. International journal of biochemistry and molecular biology, 1(1), 26.
Figure 2 Survivor functions showing prevention of HT-29 tumor growth in athymic mice by treatment with Ang antagonists.
On day 0 HT-29 cells (1.25 X 10⁵ per mouse) are mixed with PBS or the Ang antagonist and injected s.c. Daily injections of PBS or the Ang antagonist are then given for the next 35 days. (A) …, PBS (n = 145); —, mAb 26-2F (60 ,ug; n = 20); - -, mAb 36u (60 μg; n = 41); ---, mAb 26-2F + mAb 36u (30 μg of each; n = 47). (B)..., PBS (n = 145); -, bovine actin (18 μg; n = 28).
Olson, K. A., Fett, J. W., French, T. C., Key, M. E., & Vallee, B. L. (1995). Angiogenin antagonists prevent tumor growth in vivo. Proceedings of the National Academy of Sciences, 92(2), 442-446.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-64 | Recombinant Anti-human ANG Antibody | ELISA, IP, FuncS | IgG |
MHH-64 | Recombinant Human Anti-human ANG Antibody | WB, Neut, FuncS | IgG |
MOB-0614MZ | Mouse Anti-ANG Recombinant Antibody (clone 25028.8) | ELISA, IHC-Fr, IHC-P, WB | Mouse IgG1 |
MOB-321YJL | Mouse Anti-ANG Recombinant Antibody (clone 26-2F) | ELISA, ICC, IF, IHC-P, IHC-Fr, IP | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-64-F(E) | Recombinant Anti-human ANG Antibody Fab Fragment | RIA, WB, FuncS | Fab |
MHH-64-F(E) | Recombinant Human Anti-human ANG Antibody Fab Fragment | Neut, WB, FuncS | Fab |
PFBL-008 | Human Anti-ANG Recombinant Antibody (clone 26-2F); Fab Fragment | WB, IHC, IF, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-64-S(P) | Recombinant Anti-human ANG Antibody scFv Fragment | WB, IHC, FuncS | scFv |
MHH-64-S(P) | Recombinant Human Anti-human ANG Antibody scFv Fragment | FC, Neut, Biosensors, FuncS | scFv |
PSBL-008 | Human Anti-ANG Recombinant Antibody (clone 26-2F); scFv Fragment | WB, IHC, IF, FuncS | Human scFv |
There are currently no Customer reviews or questions for PABL-008. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.